Geldanamycin from MedChemExpress

Product Specs
ItemGeldanamycin
CompanyMedChemExpress
Price $55.00Supplier Page View Company Product Page
Catalog NumberHY-15230
Research AreaInflammation/Immunology; Infection; Cancer
FormulaC₂₉H₄₀N₂O₉
Molecular Weight560.64
TypeChemical
Purity99.78%
ApplicationsBioactivity, Structure and function analysis, ELISA, SDS-PAGE, Western blotting
Quantity10 mM * 1 mL

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(1) Reblastatin as a neuroprotective agent in temporal lobe epilepsy and excitotoxic conditions of Alzheimer's disease and Parkinson's diseaseActa Pharmaceutica Sinica BFebruary 26, 2026Xiuneng Zhang, Xiaolin Yu, Longze Sha, Yunfeng Li, Qi Qiao, Xiaoming Yu, Qi Xupurchased from Sigma–Aldrich (Saint Louis, MO, USA). Cycloheximide (CHX, HY-12320), 17-AAG (HY-10211), GA (HY-15230), and memantine (HY-B0591) were purchased from MedChemExpress (Shanghai, China). Additional Hsp90 inhibitor

(2) Chloroplast precursor protein preClpD overaccumulation triggers multilevel reprogramming of gene expression and a heat shock-like responseNat CommunApril 22, 2025Zheng-Hui Hong, Liyu Zhu, Lin-Lin Gao, Zhe Zhu, Tong Su, Leonard Krall, Xu-Na Wu, Ralph Bock, Guo-Zhang WuClpD-GFP line #5 were grown at half-strength MS medium supplemented with 40 µM GDA (MedChemExpress, HY-15230), 40 µM VER (MedChemExpress, HY-10941), or corresponding amount of DMSO for 6 days. Construction of

(3) Targeting Hsp90α to inhibit HMGB1-mediated renal inflammation and fibrosisCell proliferationMarch 1, 2025Wei H, Ren J, Feng X, Zhao C, Zhang Y, Yuan H, Yang F, Li Q.bought from R&D Systems (210‐TA‐020) located in Minneapolis, MN, USA. GA (HY‐N0184) and geldanamycin (HY‐15230) were obtained from MCE (Beijing, China). Antibodies against collagen type I (COL1; ab270946), FN (ab2413),

(4) A Cullin 5-based complex serves as an essential modulator of ORF9b stability in SARS-CoV-2 replicationSignal Transduction and Targeted TherapyJune 28, 2024Yuzheng Zhou, Zongpeng Chen, Sijie Liu, Sixu Liu, Yujie Liao, Ashuai Du, Zijun Dong, Yongxing Zhang, Xuan Chen, Siyi Tao, et al.5’-GGAAAGAGCUGCAUAUUAATT-3’ HSP90β: 5’-GGAGAUUUUCCUUCGGGAGTT-3’ TOM70: 5’-GGCAUUAACAGAUCAACA-3’ Geldanamycin (HY-15230) and 17-AAG (HY10211) were purchased from MedChemExpress. Animal experiments C57BL/6 mice aged 6–8

(5) Deficiency in Prader-Willi syndrome gene necdin leads to attenuated cardiac contractilityiScienceJune 21, 2024Yufan Dong, Renbin Lu, Hui Cao, Jing Zhang, Xiushan Wu, Yun Deng, Jia-Da Liproteins","Chemicals, peptides, and recombinant proteins" ,, CHX,AbMole,M4879 MG-132,MCE,HY-13259 Geldanamycin,MCE,HY-15230 17-AAG,MCE,HY-10211 ,, Critical commercial assays,Critical commercial assays,Critical commercial

(6) Thymoquinone affects hypoxia-inducible factor-1α expression in pancreatic cancer cells via HSP90 and PI3K/AKT/mTOR pathwaysWorld Journal of GastroenterologyJune 7, 2024Zhan-Xue Zhao, Shuai Li, Lin-Xun Liu(HY-D0803; MCE; New Jersey; United States); 26S proteasome inhibitor (HY-132598; MCE); geldanamycin (GA; HY-15230; MCE); cycloheximide (CHX) (S7418; SELLECK; Houston; United States); dimethyl sulfoxide (DMSO; Sigma;

(7) QHRD106 ameliorates ischemic stroke injury as a long-acting tissue kallikrein preparationiScienceJuly 21, 2023Xu SY, Jia JQ, Sun M, Bao XY, Xia SN, Shu S, Liu PY, Ji SL, Ye L, Cao X, et al.and recombinant proteins" ,, HOE-140,MedChemExpress,Cat#HY-17446 Geldanamycin,MedChemExpress,Cat#HY-15230 R-715,Tocris Bioscience,Cat#3407 LPS,Sigma-Aldrich,L6529 ,, Deposited data,Deposited data,Deposited

(8) PIF7 is a master regulator of thermomorphogenesis in shadeNature CommunicationsAugust 29, 2022Yogev Burko, Björn Christopher Willige, Adam Seluzicki, Ondřej Novák, Karin Ljung, Joanne ChoryN-1-naphthylphthalamic acid (NPA, N6250, PhytoTechLABS), peo-IAA (HY-112730, MCE), geldanamycin (GDA, HY-15230, MCE), or DMSO control and grown under the indicated conditions for the indicated times. Real-time PCR

(9) Necdin regulates BMAL1 stability and circadian clock through SGT1-HSP90 chaperone machineryNucleic acids researchAugust 20, 2020Lu R, Dong Y, Li JD.Invitrogen. Antibody against GRP (20073) were obtained from ImmunoStar. 17-AAG (HY-10211) and Geldanamycin (HY-15230) were purchased from MedChemExpress. Animals Necdin mice were generated by using CRISPR-Cas9 technology.

(10) Geldanamycin Reduces Acute Respiratory Distress Syndrome and Promotes the Survival of Mice Infected with the Highly Virulent H5N1 Influenza VirusFrontiers in cellular and infection microbiologyJanuary 1, 2017Wang C, Liu P, Luo J, Ding H, Gao Y, Sun L, Luo F, Liu X, He H.

(11) Viperin inhibits rabies virus replication via reduced cholesterol and sphingomyelin and is regulated upstream by TLR4Scientific reportsJuly 26, 2016Tang HB, Lu ZL, Wei XK, Zhong TZ, Zhong YZ, Ouyang LX, Luo Y, Xing XW, Liao F, Peng KK, et al.

(12) 17-ABAG, a novel geldanamycin derivative, inhibits LNCaP-cell proliferation through heat shock protein 90 inhibitionInternational journal of molecular medicineAugust 1, 2015Lin Z, Peng R, Li Z, Wang Y, Lu C, Shen Y, Wang J, Shi G.

(13) RIP1 mediates the protection of geldanamycin on neuronal injury induced by oxygen-glucose deprivation combined with zVAD in primary cortical neuronsJournal of neurochemistryJanuary 1, 2012Chen WW, Yu H, Fan HB, Zhang CC, Zhang M, Zhang C, Cheng Y, Kong J, Liu CF, Geng D, et al.

(14) Structural basis for inhibition of the Hsp90 molecular chaperone by the antitumor antibiotics radicicol and geldanamycinJournal of medicinal chemistryJanuary 28, 1999Roe SM, Prodromou C, O'Brien R, Ladbury JE, Piper PW, Pearl LH.

(15) [New technics for extraction and identification of certain venoms; alkaloids, barbiturates and glucosides]Archivio di scienze biologicheSeptember 1, 1952ROMANO C.

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Geldanamycin from MedChemExpress

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Geldanamycin from MedChemExpress

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