Tauroursodeoxycholate from MedChemExpress

Product Specs
ItemTauroursodeoxycholate
CompanyMedChemExpress
Price $66.00Supplier Page View Company Product Page
Catalog NumberHY-19696
Quantity10 mM * 1 mL
ApplicationsBioactivity, Structure and function analysis, ELISA, SDS-PAGE, Western blotting
Purity99.93%
TypeChemical
Molecular Weight499.7
FormulaC₂₆H₄₅NO₆S
Research AreaCancer

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(1) Toxoplasma gondii effector GRA35 mediates neuronal damage via ER stress and mitochondria-associated apoptosisVirulenceApril 6, 2026Jie Wang, Ying Chen, Nan Zhou, Fangmin Li, Niuniu Dai, Zhiang Chen, Shutong Liu, Ran An, Lijian Chen, Jian Duladder (Catalog #: WJ103) purchased from Epizyme. GSK2606414(Catalog #: HY-18072), TUDCA(Catalog #: HY-19696), Tunicamycin(Catalog #: HY-A0098) all purchased from MCE. Animals and Toxoplasma gondii The C57BL/6

(2) Free Fatty Acids Induce Endoplasmic Reticulum Stress-Mediated Apoptosis of Macrophages in Dairy Cows with KetosisAnimals (Basel)April 1, 2026Hongdou Jia, Xinyuan Sun, Wantong Cheng, Yue Yu, Yutong Wu, Jiayi Yan, Yunhui Fan, Qiushi Xu, Juan J. Loor, Chuang Xu, et al.(Tn, HY-A0098, MCE, Monmouth Junction, NJ, USA) and the ERS inhibitor tauroursodeoxycholate (TUDCA, HY-19696, MCE, Monmouth Junction, NJ, USA). Briefly, cells were cultured with 500 μg/mL TUDCA or DMSO (solvent,

(3) Multi-omics analysis identifies a microbiota–bile acid–TLR signaling axis driving bladder injury in interstitial cystitisNature CommunicationsDecember 29, 2025Liao Peng, Jia-wei Chen, Yuan-zhuo Chen, Xing-peng Di, Le-de Lin, Bo-ya Li, Chi Zhang, Wei Wang, Xiao-shuai Gao, Yu-cheng Ma, et al.taurochenodeoxycholic acid (TCDCA, MCE, Cat. HY-N2027) or tauroursodeoxycholic acid (TUDCA, MCE, Cat. HY-19696) for 24 h, followed by a CCK-8 assay to assess cytotoxicity. Based on the results, exposure to 200 μM

(4) Enterotoxigenic Escherichia coli (ETEC) Infection Triggers Pyroptosis Through ER Stress Response-Mediated Mitochondrial Impairment and STING Activation in Intestinal Epithelial CellsBiology (Basel)November 23, 2025Wenjie Yang, Xi Qiu, Jianan Guo, Yongxiang Wang, Jie Wang, Hongliang Chen, Di Zhang, Lei Zhangof 1 × 1010 CFU/mL ETEC via intragastric gavage. The TUDCA group (4 mice) received 150 μg/g TUDCA (HY-19696, MCE, Shanghai, China) via intragastric gavage. The ETEC + TUDCA group (4 mice) received 200 μL of 1

(5) Cholecystectomy-related gut microbiota dysbiosis exacerbates colorectal tumorigenesisNat CommunAugust 16, 2025Bo Tang, Shengpeng Li, Xin Li, Jialin He, An Zhou, Lingyi Wu, Xu Xiao, Sumin Wang, Hongfei Jiang, Jincheng Jian, et al.or TUDCA or UDCA supplementation 400 mg/kg freshly prepared GUDCA (Solarbio, IG0840) or TUDCA (MCE, HY19696), dissolved in corn oil, was orally gavaged twice a week during administration with AOM/DSS. In addition,

(6) Toxoplasma TgCtwh3 Δrop16 Ⅰ/Ⅲ accelerates neuronal apoptosis and APP production in mouse with acute infectionIBRO Neuroscience ReportsJune 1, 2025Di Yang, Cong Wang, Qing Tao, Lei Liu, Mengmeng Jin, Haiping Cai, Meijuan Zheng, Mengtao Gong, Li Yu, Jian Du, et al.Tauroursodeoxycholate sodium (Tauroursodeoxycholic acid, TUDCA, an endoplasmic reticulum stress inhibitor, Cat# HY-19696), 4-Methyl-N1-(3-phenylpropyl)-1,2-phenylenediamine (JSH-23, NF-κB activation inhibitor, Cat# HY-13982)

(7) Dehydrocorydaline attenuates bleomycin-induced pulmonary fibrosis by inhibiting fibroblast activationRespir ResApril 12, 2025Jianhan He, Huihui Yue, Shufei Zhang, Ruihan Dong, Fengqin Zhang, Xuewen Wang, Ke Wang, Huilan Zhang, Danlei Yang, Zhaoxing Dong, et al.4-Phenylbutyric acid and Thapsigargin were acquired from MedChemExpress (HY-N0674, HY-17565A, HY-A0281, HY-13433, HY-19696). Recombinant TGF-β1 was obtained from PeproTech (100-21). Antibodies against Fibronectin, β-actin,

(8) Endoplasmic reticulum stress aggravates ferroptosis via PERK/ATF4/HSPA5 pathway in UUO-induced renal fibrosisFront PharmacolApril 4, 2025Zhigang Huang, Lihua Zhou, Bin Liu, Xiaoju Li, Yu SangTauroursodeoxycholate (TUDCA) group were administered intraperitoneal injections of 150 mg/kg/day TUDCA (HY-19696, MedChemExpress, United States) dissolved in PBS before UUO surgery. Six mice from each experimental

(9) Andrographolide ameliorates sepsis-induced acute liver injury by attenuating endoplasmic reticulum stress through the FKBP1A-mediated NOTCH1/AK2 pathwayCell Biol ToxicolMarch 7, 2025Jiaqi He, Zepeng Huang, Rui ZouD-galactosamine and LPS to develop the ALI mouse model. The ER stress inhibitor tauroursodeoxycholate (TUDCA, HY-19696, MedChemExpress, Monmouth Junction, NJ, USA) was added to drinking water at a dose of 0.5 g/kg/day (same

(10) Ursodeoxycholic acid inhibits the uptake of cystine through SLC7A11 and impairs de novo synthesis of glutathioneJournal of Pharmaceutical AnalysisJanuary 1, 2025Fu'an Xie, Yujia Niu, Xiaobing Chen, Xu Kong, Guangting Yan, Aobo Zhuang, Xi Li, Lanlan Lian, Dongmei Qin, Quan Zhang, et al.acid (DCA; 30960) were purchased from Sigma (Darmstadt, Germany‌‌). Tauroursodeoxycholic acid (TDCA) (HY-19696), RSL3 (HY-100218A), erastin (HY-15763), RG7112 (HY-10959), nutlin-3a (HY-10029), abemaciclib (HY-16297A),

(11) Lithocholic acid phenocopies anti-ageing effects of calorie restrictionNatureDecember 18, 2024Qi Qu, Yan Chen, Yu Wang, Shating Long, Weiche Wang, Heng-Ye Yang, Mengqi Li, Xiao Tian, Xiaoyan Wei, Yan-Hui Liu, et al.(MAK134). Vancomycin (V32969) was purchased from InvivoChem. CA (HY-N0324), CDCA (HY-76847), TUDCA (HY-19696), TCA (HY-B1788), 1-methyladenosine (HY-113081) and diprotin A (HY-111174) were purchased from MedChemExpress.

(12) TUDCA alleviates atherosclerosis by inhibiting AIM2 inflammasome and enhancing cholesterol efflux capacity in macrophageiScienceJune 21, 2024Xuyang Wang, Yuesheng Zhang, Luping Du, Zhengchen Jiang, Yan Guo, Kai Wang, Yijiang Zhou, Xiang Yin, Xiaogang GuoHeatmap and volcano plot were drawn by the R package limma. Cell culture and treatment TUDCA (MCE, HY-19696) with different concentrations (1μM, 2μM, 5μM, 10μM, 20μM) was added in THP1 macrophages and RAW264.7

(13) Miriplatin-loaded liposome, as a novel mitophagy inducer, suppresses pancreatic cancer proliferation through blocking POLG and TFAM-mediated mtDNA replicationActa Pharmaceutica Sinica BNovember 1, 2023Xiaowei Wang, Mengyan Wang, Meilian Cai, Rongguang Shao, Guimin Xia, Wuli Zhaoendoplasmic reticulum (ER) stress inhibitors 4-phenylbutyric acid (4-PBA, HY-A0281) and tauroursodeoxycholate (TUDCA, HY-19696) were all bought from MedChemExpress (Shanghai, China). DiI (D-282), lipofectamine 2000 (11668019) and

(14) HMMR alleviates endoplasmic reticulum stress by promoting autophagolysosomal activity during endoplasmic reticulum stress-driven hepatocellular carcinoma progressionCancer communications (London, England)September 1, 2023He L, Li H, Li C, Liu ZK, Lu M, Zhang RY, Wu D, Wei D, Shao J, Liu M, et al.tunicamycin (TM; HY‐A0098, MedChemExpress, Shanghai, China), 100 μmol/L tauroursodeoxycholate (TUDCA; HY‐19696, MedChemExpress) or 50 nmol/L bafilomycin A1 (Baf A1; ab120497, Abcam). The reagents were dissolved

(15) PARP1-catalyzed PARylation of YY1 mediates endoplasmic reticulum stress in granulosa cells to determine primordial follicle activationCell death & diseaseAugust 15, 2023Chen W, E Q, Sun B, Zhang P, Li N, Fei S, Wang Y, Liu S, Liu X, Zhang X.with 50 nM of Tunicamycin (TM, #HY-A0098, MedChemExpress), or 50 μM of Tauroursodeoxycholate (TUDCA, #HY-19696, MedChemExpress), dimethylsulfoxide (DMSO) was used as a control. The ovary transfection was performed

(16) β‐asarone inhibits the migration, invasion, and EMT of bladder cancer through activating ER stressCancer MedicineJune 12, 2023Bo Liu, Weichao Dan, Yi Wei, Yan Zhang, Chi Wang, Yuzeshi Lei, Tao Hou, Yong Zhang, Ye GaoMedChemExpress and dissolved in dimethyl sulfoxide (DMSO). Tauroursodeoxycholic acid (TUDCA; cat. no. HY‐19696) was purchased from MedChemExpress. Primary rabbit antibodies against ATF6 (cat. no. ab37149; 1:2000),

(17) Development of a cell-free screening assay for the identification of direct PERK activatorsPLOS ONEMay 18, 2023Márcia F. D. Costa, Günter U. Höglinger, Thomas W. Röslerof the PERK pathway, GSK2606414 (HY-18072), CCT020312 (HY-119240), TUDCA (tauroursodeoxycholic acid; HY-19696), resveratrol (HY-16561), metformin (HY-B0627) and compound MK-28 (HY-137207) were obtained from MedChemExpress

(18) Mechanism of Endoplasmic Reticulum Stress Pathway in the Osteogenic Phenotypic Transformation of Aortic Valve Interstitial CellsFrontiers in endocrinologyJanuary 1, 2022Tao Y, Geng Y, Dang W, Xu X, Zhao H, Zou L, Li Y.into four groups: CTL group, ox-LDL group (100 μg/mL), ox-LDL group (100 μg/ml) +TUDCA (100umol/L, HY-19696, MCE) group and TUDCA (1mmol/L) group, in which ox-LDL (100 μg/ml) +TUDCA group cells were treated with

(19) Tauroursodeoxycholic Acid Attenuates Angiotensin II Induced Abdominal Aortic Aneurysm Formation in Apolipoprotein E-deficient Mice by Inhibiting Endoplasmic Reticulum StressEuropean journal of vascular and endovascular surgery : the official journal of the European Society for Vascular SurgeryMarch 1, 2017Qin Y, Wang Y, Liu O, Jia L, Fang W, Du J, Wei Y.

(20) Tauroursodeoxycholate (TUDCA) inhibits neointimal hyperplasia by suppression of ERK via PKCα-mediated MKP-1 inductionCardiovascular researchNovember 1, 2011Kim SY, Kwon YW, Jung IL, Sung JH, Park SG.

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Tauroursodeoxycholate from MedChemExpress

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Tauroursodeoxycholate from MedChemExpress

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