T0901317 from MedChemExpress

Product Specs
ItemT0901317
CompanyMedChemExpress
Price $73.00Supplier Page View Company Product Page
Catalog NumberHY-10626
Quantity10 mM * 1 mL
ApplicationsBioactivity, Structure and function analysis, ELISA, SDS-PAGE, Western blotting
Purity99.93%
TypeChemical
Molecular Weight481.33
FormulaC₁₇H₁₂F₉NO₃S
Research AreaMetabolic Disease; Cardiovascular Disease; Cancer

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(1) GCN5 drives MASLD progression through LXRα/SREBP1c signaling pathway–mediated de novo lipogenesisNature CommunicationsFebruary 16, 2026Hai-Tao Xiao, Peng Song, Jing Jin, Yong-Dan Wang, Yin-Yue Xu, He Wu, Xue-Xue Shao, Qi-Feng Gan, Jian He, Yan-Rong Wen, et al.ChIP Plus Sonication Chromatin IP Kit (56383S) was purchased from Cell Signaling Technology. T0901317 (HY-10626), GW3965 (HY-10627), and CPTH2 (HY-W013274) were purchased from MedChemExpress. Anti-mouse horseradish

(2) Active LXR signaling, coupled with elevated mitochondrial and glycolytic metabolism contributes to GM-CSF–induced trained immunityFrontiers in ImmunologyJanuary 7, 2026Yuanyuan Liu, Arslan Hamid, Hannah Hardege, Qian Zhang, Helena Körner, Merle Leffers, Noelia A. Gonzalez, Gerhard Liebisch, Marcus Hoering, Hannes Findeisen, et al.(ImmonoTools, #11343115) in the presence or absence of 1 μM GW3965 (Cayman, #10054) or 1 μM T0901317 (T13) (#HY-10626 MCE), 2.5 μM GSK2033 (LXR antagonist, Cayman, #25443), 10 μM 3PO (PFKFB3 inhibitor, Axonmedchem, #2175),

(3) Depletion of Hepatic SREBP2 Protects Against Hypercholesterolemia and Atherosclerosis through the ANGPTL3‐LPL AxisAdvanced ScienceMarch 19, 2025Yifan Wang, Jia You Sarafina Choe, Yu Shi, Thi Tun Thi, Xiaoyun Cao, Yang Hu, Kai Yan Cheng, Hui Li, Yang Ji, Yan Liu, et al.with different chemicals or supplements (1uM LXR agonist T0901317 dissolved in DMSO (MedChemExpress, HY‐10626) or 50 um Cholesterol–methyl‐β‐cyclodextrin dissolved in H2O (Sigma‐Aldrich, C4951) or 10 um Simvastatin

(4) Cholesterol-mediated Lysosomal Dysfunction in APOE4 Astrocytes Promotes α-Synuclein Pathology in Human Brain TissuebioRxivFebruary 14, 2025Louise A. Mesentier-Louro, Camille Goldman, Alain Ndayisaba, Alice Buonfiglioli, Rikki B. Rooklin, Braxton R. Schuldt, Abigail Uchitelev, Vikram Khurana, Joel W. BlanchardμM (MedChemExpress HY10572) LXR-623: 10 μM (MedChemExpress HY-10629) T0901317: 10 μM (MedChemExpress HY-10626) Extended Data Supplementary Material

(5) First-in-Class Small Molecule Degrader of Pregnane X Receptor Enhances Chemotherapy EfficacyJournal of medicinal chemistryOctober 24, 2024Huber AD, Jung YH, Li Y, Lin W, Wu J, Poudel S, Carrigan AG, Mishra A, High AA, Chen T.Rifampicin (cat. # R3501) and MG132 (cat. # 474790) were purchased from Sigma-Aldrich. T0901317 (cat. # HY-10626) and MLN4924 (cat. # HY-70062) were purchased from MedChemExpress. The PXR ligands SPA70, SJB7, SJPYT-328,

(6) miR-3529-3p/ABCA1 axis regulates smooth muscle cell homeostasis by enhancing inflammation via JAK2/STAT3 pathwayFrontiers in Cardiovascular MedicineAugust 27, 2024Tingyu Wang, You Yu, Yinglong Ding, Ziying Yang, Shumin Jiang, Faxiong Gao, Shan Liu, Lianbo Shao, Zhenya Shenexpression Subconfluent HASMCs were treated with T0901317 (a liver X receptor agonist, MedChemExpress, HY-10626) for 12 h to stimulate ABCA1 expression as previous reported (20). The HASMCs treated solely with DMSO

(7) Ficolin 3 promotes ferroptosis in HCC by downregulating IR/SREBP axis-mediated MUFA synthesisJournal of Experimental & Clinical Cancer ResearchMay 3, 2024Yanmei Yuan, Junting Xu, Quanxin Jiang, Chuanxin Yang, Ning Wang, Xiaolong Liu, Hai-long Piao, Sijia Lu, Xianjing Zhang, Liu Han, et al.contamination every month. FCN3-overexpressed MHCC97-H, YY-8103 and control cells were treated with T0901317 (HY-10626, MedChemExpress), Erastin (HY-15736, MedChemExpress), FINO2 (HY-129457, MedChemExpress), AKTi-1/2 (HY-10355,

(8) Transcriptional characterization of iPSC-derived microglia as a model for therapeutic development in neurodegenerationScientific ReportsJanuary 25, 2024Gokul Ramaswami, Yeliz Yuva-Aydemir, Brynn Akerberg, Bryan Matthews, Jenna Williams, Gabriel Golczer, Jiaqi Huang, Ali Al Abdullatif, Dann Huh, Linda C. Burkly, et al.dimethyl sulfoxide (DMSO) or different doses (30 nM or 100 nM) of T0901317 (MedChemExpress LLC, Cat. No. HY-10626) and GW3965 (30 nM or 300 nM) (MedChem Express LLC, Cat. No. HY-10627A) and incubated for 24 h. After

(9) Regulatory roles of external cholesterol in human airway epithelial mitochondrial function through STARD3 signallingClinical and translational medicineJune 1, 2022Li L, Liu Y, Liu X, Zheng N, Gu Y, Song Y, Wang X.purchased from ATCC (CRL‐9609) and cultured in DMEM (SH30243.01, Hyclone, Logan, UT, USA). T0901317 (HY‐10626), GW3965 (HY‐10627), rapamycin and atorvastatin (HY‐B0589) were purchased from MedChemExpress, NJ, USA.

(10) Beneficial and Adverse Effects of an LXR Agonist on Human Lipid and Lipoprotein Metabolism and Circulating NeutrophilsCell metabolismAugust 9, 2016Kirchgessner TG, Sleph P, Ostrowski J, Lupisella J, Ryan CS, Liu X, Fernando G, Grimm D, Shipkova P, Zhang R, et al.

(11) The liver X receptor agonist T0901317 protects mice from high fat diet-induced obesity and insulin resistanceThe AAPS journalJanuary 1, 2013Gao M, Liu D.

(12) Anti-proliferative effect of LXR agonist T0901317 in ovarian carcinoma cellsJournal of ovarian researchMay 26, 2010Rough JJ, Monroy MA, Yerrum S, Daly JM.

(13) The benzenesulfoamide T0901317 [N-(2,2,2-trifluoroethyl)-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-benzenesulfonamide] is a novel retinoic acid receptor-related orphan receptor-alpha/gamma inverse agonistMolecular pharmacologyFebruary 1, 2010Kumar N, Solt LA, Conkright JJ, Wang Y, Istrate MA, Busby SA, Garcia-Ordonez RD, Burris TP, Griffin PR.

(14) T0901317 is a dual LXR/FXR agonistMolecular genetics and metabolismSeptember 1, 2004Houck KA, Borchert KM, Hepler CD, Thomas JS, Bramlett KS, Michael LF, Burris TP.

(15) Role of LXRs in control of lipogenesisGenes & developmentNovember 15, 2000Schultz JR, Tu H, Luk A, Repa JJ, Medina JC, Li L, Schwendner S, Wang S, Thoolen M, Mangelsdorf DJ, et al.

(16) Fatigue and recovery of the human acoustic stapedius reflex in industrial noiseThe Journal of the Acoustical Society of AmericaMarch 1, 1979Borg E, Nilsson R, Lidén G.

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T0901317 from MedChemExpress

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T0901317 from MedChemExpress

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