Dynasore from MedChemExpress

Product Specs
ItemDynasore
CompanyMedChemExpress
Price $99.00Supplier Page View Company Product Page
Catalog NumberHY-15304
Quantity10 mM * 1 mL
ApplicationsBioactivity, Structure and function analysis, ELISA, SDS-PAGE, Western blotting
Purity99.66%
TypeChemical
Molecular Weight322.31
FormulaC18H14N2O4
Research AreaMetabolic Disease
Molecule NameDynasore

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(1) Extracellular biogenic nanoscale mitochondria reprogram the wound microenvironment via ROS scavenging independent of cellular uptakeMaterials Today BioJune 1, 2026Fang Lin, Jing Liu, Yue Ding, Kexin Ma, Qingshu Meng, Xiaohui Zhou, Qingliu Zhang, Hao Hu, Zhongmin Liu, Xiaoting Liangrotenone (500 nM; MCE, Cat# HY-B1756), PX-12 (10 μM; MCE, Cat# HY-13734), Dynasore (5 μM; MCE, Cat# HY-15304), MNS (1 μM; MCE, Cat# HY-78263), EIPA (20 μM; MCE, Cat# HY-101840), LY294002 (50 μM; MCE, Cat# HY-10108),

(2) PKC-iota drives EGFR-TKI resistance in EGFR-mutated NSCLC by phosphorylating FASN to reprogram lipid metabolismTranslational Lung Cancer ResearchFebruary 28, 2026Lin Ma, Yingwen Han, Lunran Xu, Qingyuan Sun, Siyue Song, Huizhen Yang, Xinran Chen, Wenhui Xie, Yumei Chen, Liu LiuEGFT-TKIs gefitinib (HY-50895, MCE), afatinib (HY-10261, MCE), and osimertinib (HY-15772, MCE); Dynasore (HY-15304, MCE); Pitstop2 (HY-115604, MCE); TMA-DPH (HY-D0986, MCE); EGF (HY-P7109, MCE). Plasmid, siRNA, and transfection

(3) Tumour-infiltrating microplastics disrupt the JAK-STAT-microbiota axis to promote immunotherapy resistance in colorectal cancerMolecular CancerFebruary 10, 2026Zhaohui Jiang, Yongting Liu, Peng Zhang, Jiang Fei, Kailing Wang, Yin Li, Xiangyang Zhang, Changjing Cai, Yihong Chen, Yinghui Peng, et al.(AOM, #183971) was purchased from MP Biomedicals. Dextran sulfate sodium (DSS, #HY-116282), Dynasore (#HY-15304), Pitstop 2 (#HY-115604), EIPA (#HY-101840), and 2-NP (#HY-W013523) were purchased from MCE. An anti-mouse

(4) Neutrophil extracellular traps prime the ZBP1-cGAS sensor complex, triggering necroptosis and inflammatory injury in acute pancreatitisInternational Journal of Biological SciencesFebruary 4, 2026Haoyu Zhang, Zheng Wang, Jiongdi Lu, Jie Li, Yuchen Jia, Xiaozhou Xie, Yixuan Ding, Feng Cao, Fei Licyclosporin A (CsA, HY-B0579), Z-VAD (HY-164388), GSK872 (HY-101872), DNase I (HY-108882), Dynasore (HY-15304), phorbol 12-myristate 13-acetate (PMA, HY-18739) were purchased from MCE. Quant-iT™ PicoGreen™ dsDNA assay kit

(5) Biomimetic Nanomedicine for Senescence‐Modulated Immune Activation Enhances Immunotherapy Efficacy in Hepatocellular CarcinomaAdvanced ScienceFebruary 1, 2026Shiji Fang, Liyun Zheng, Bin Lin, Jiale Chen, Dehai Hou, Yiming Ding, Mengzhu Han, Pan Qin, Mengyuan Wang, Xiaoju Guo, et al.obtained from Sangon Biotechnology. Piperlongumine (HY‐N2329), chlorpromazine (HY‐12708), dynasore (HY‐15304), N‐acetylcysteine (HY‐B0215), palbociclib (HY‐50767) were purchased from MedChemExpress (MCE, USA).

(6) Extracellular vesicles from IPFP-MSCs trigger osteoarthritis by transferring mtDNABioact MaterDecember 11, 2025Shiyu Li, Zi Yan, Xinwang Zhi, Weihan Zheng, Ziqi Zhang, Zhenning Dai, Wanying Chen, Hui Lu, Ziyi Feng, Ting Cheng, et al.contrast-labeled with DAPI for 5 min before final mounting. The uptake inhibitors Dynasore (20 μM; HY-15304, MedChemExpress, USA), Cytochalasin D (5 μM; HY-N6682, MedChemExpress, USA), Amiloride (200 μM; MK-870,

(7) Platelet-bioengineered hiPSC-sEVs achieve targeted repair of fibrotic sinoatrial node in preclinical SND modelsNat CommunDecember 9, 2025Hanfeng Liu, Yangxi Zeng, Wei Fan, Xi Lan, Can Liu, Yisong He, Zhaoting Li, Kewei Jia, Juyi Wan, Bin Liaoused for the experiments. DiI-labeled PM@i-sEVs were co-incubated with cells for 12 h, while Dynasore (HY-15304, MCE), a dynamin-dependent endocytosis inhibitor, was applied to the cells. Fluorescence microscopy

(8) Ribosome remodeling drives translation adaptation during viral infection and cellular stressbioRxivOctober 28, 2025Hsin-Yu Tsai, Luochen Liu, Rebecca H. Fleming, Julian Mintseris, Derrick Ekanayake, Xin Gu, Steven P. Gygi, Amy S.Y. Leeof infection. To inhibit viral entry, HEK293T cells were pre-treated with 80 μM Dynasore inhibitor (HY-15304, MedChemExpress) or 100 nM Bafilomycin A1 (HY-100558, MedChemExpress) for 30 min before virus addition. VSV

(9) SFTSV utilizes AXL/GAS6 for entry via PI3K-PLC-dependent macropinocytosis activated by AXL-kinaseJournal of VirologySeptember 23, 2025Zecheng Jin, Shuhei Taguwa, Junki Hirano, Kentaro Uemura, Chikako Ono, Akatsuki Saito, Tamaki Okabayashi, Yusuke Maeda, Taroh Kinoshita, Yoshiharu MatsuuraUSA), pictilisib (HY-50094, MCE), U73122 (HY-13419, MCE), cytochalasin D (HY-N6682, MCE), dynasore (HY-15304, MCE), CPZ (S5749, Selleck, Houston, TX, USA), pitstop 2 (HY115604, MCE), NSC23766 (HY-15723A, MCE),

(10) Gut-derived bacterial vesicles carrying lipopolysaccharide promote microglia-mediated synaptic pruningAlzheimer's & dementia : the journal of the Alzheimer's AssociationAugust 1, 2025Zhao X, Yu J, Xu B, Xu Z, Lei X, Han S, Luo S, Zhang C, Peng G, Li J, et al.particles/mL) from human feces for 24 h. 5 µM GsMTx4 was used to inhibit Piezo1, and 10 µM dynasore (HY‐15304, MCE, USA) was used to inhibit endocytosis of bEVs in HMC3 cells. Cells were subsequently collected

(11) AGR2-mediated cell-cell communication controls the antiviral immune response by promoting the thiol oxidation of TRAF3Redox BiolMarch 4, 2025Mengqi Jia, Xiaojing Chen, Wenxue Guo, Dapeng Ma, Peng Wang, Huanmin Niu, Changhong Liu, Xianjuan Lin, QiQi Lu, Jing Wang, et al.Thermo Fisher Scientific. Poly (I:C) HMW (tlrl-pic) was purchased from InvivoGen. Amiloride (HY–B0285), dynasore (HY-15304), maleimide (HY–W007324), methyl-β-cyclodextrin (Mβ-CD) (HY-101461), nocodazole (HY-13520), and nystatin

(12) Apoptotic vesicles derived from bone marrow mesenchymal stem cells increase angiogenesis in a hind limb ischemia model via the NAMPT/SIRT1/FOXO1 axisStem Cell Res TherMarch 1, 2025Jinxing Chen, Zekun Shen, Bingyi Chen, Shuang Liu, Yifan Mei, Kai Li, Ziyang Peng, Chaoshuai Feng, Weiyi Wang, Shaoying LuHUVECs. For ApoVs uptake inhibitors, HVUECs were first incubated in complete medium containing dynasore (#HY-15304, MCE, 12.5–100 µM), chlorpromazine (#HY-12708, MCE, 6.25-50 µM), Pitstop 2 (#HY-115604, MCE, 12.5–100

(13) Tumor cell-derived hyaluronan fragments induce endocytosis of S1PR1 to promote lymphangiogenesis through LYVE-1-Src pathwayJournal of CancerJanuary 27, 2025Mengying Jiang, Dandan Chen, Zhangrun Xu, Yiwen Liu, Cuixia Yang, Guoliang Zhang, Qian Guo, Feng Gao, Yiqing He, Yan DuAgonist Sphingosine-1-phosphate (S1P, HY-108496, MedChemExpress, NJ, USA) and inhibitors dynasore (HY-15304, MedChemExpress, NJ, USA), PP2 (T6266, TOPSCIENCE, Shanghai, China) were used. In vivo experiments All

(14) Palmitoylation regulates myelination by modulating the ZDHHC3-Cadm4 axis in the central nervous systemSignal Transduction and Targeted TherapySeptember 26, 2024Yanli Chang, Jiangli Zhu, Xiaopeng Li, Yi Deng, Birou Lai, Yidan Ma, Jia Tong, Huicong Liu, Juanjuan Li, Chenyu Yang, et al.Sigma, C6628), 3 mM 3-Methyladenine(3-MA, MedChemExpress, HY-19312) and 80 μM dynasore (MedChemExpress,HY-15304). All drug experiments were started at 12 h after cells were transfected. Cells were exposed to fresh

(15) Internalisation of neutrophils extracellular traps by macrophages aggravate rheumatoid arthritis via Rab5aRMD OpenMarch 14, 2024Haixin Ye, Qian Yang, Huaxia Guo, Xing Wang, Lifang Cheng, Bingqi Han, Mukeng Hong, Fopei Ma, Meng Li, Xianghui Wu, et al.for 1, 2 or 6 hours. To investigate the NETs location, BMDMs were pretreated with 1 µg/mL Dynasore (HY-15304, MedChemExpress, USA),26 27 or 40 µg/mL of Bafilomycin-A1 (HY-100558, MedChemExpress, USA) for 30 min

(16) A Novel Pathway of Functional microRNA Uptake and Mitochondria DeliveryAdvanced science (Weinheim, Baden-Wurttemberg, Germany)August 1, 2023Liu J, Li W, Li J, Song E, Liang H, Rong W, Jiang X, Xu N, Wang W, Qu S, et al.(Invitrogen), cytochalasin B (APExBio, A8487), rottlerin (Abcam, Ab120377), dynasore (MedChemExpress, HY‐15304), nocodazole (APExBio, A8487), EIPA (MedChemExpress, HY‐101840), Dibucaine (MedChemExpress, HY‐B0552),

(17) Rab27a-mediated extracellular vesicle secretion contributes to osteogenesis in periodontal ligament-bone niche communicationScientific reportsMay 25, 2023Lu Y, Zhao L, Mao J, Liu W, Ma W, Zhao B.were pretreated with dynasore [100 μM from a stock solution of 100 mM in dimethyl sulfoxide (DMSO); HY-15304, MCE], methyl-β-cyclodextrin (MβCD, 250 μM from a stock solution of 100 mM in DMSO) (ST1515, Beyotime)

(18) LAMTOR1 degrades MHC-II via the endocytic in hepatocellular carcinomaCarcinogenesisDecember 25, 2022Wu B, Wang Q, Li B, Jiang M.#ab126722;Abcam) and anti-MHC-II (catalog #ab55152;Abcam). The reagents used were: 1 μM Dynasore (catalog #HY-15304;MedChemExpress), 5 mM 3-methyl adenine (3-MA;autophagy inhibitor) (catalog #HY-19312; MedChemExpress)

(19) Intestinal epithelial β Klotho is a critical protective factor in alcohol-induced intestinal barrier dysfunction and liver injuryEBioMedicineAugust 1, 2022Hou Z, Ding Q, Li Y, Zhao Z, Yan F, Li Y, Wang X, Xu J, Chen W, Wu G, et al.MG-132 (MedChemExpress cat#HY-13259) was used at 2 µg/ml for 24 h and Dynasore (MedChemExpress cat#HY-15304) was used at 50 µM for 30 min. Immunofluorescence staining Cells or frozen tissue sections were fixed

(20) Domain fusion TLR2-4 enhances the autophagy-dependent clearance of Staphylococcus aureus in the genetic engineering goateLifeJune 28, 2022Wang M, Qi Y, Cao Y, Zhang X, Wang Y, Liu Q, Zhang J, Zhou G, Ai Y, Wei S, et al.Extraction Kits for Cells,Invent Biotechnologies,Cat#: SC-003, "Chemical compound, drug",Dynasore,MCE,Cat#: HY-15304,50 μM "Chemical compound, drug",SP600125,MCE,Cat#: HY-12041,200 μM "Chemical compound, drug",PD98059,MCE,Cat#:

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Dynasore from MedChemExpress

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Dynasore from MedChemExpress

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