Busulfan from MedChemExpress

Product Specs
ItemBusulfan
CompanyMedChemExpress
Price $61.00Supplier Page View Company Product Page
Catalog NumberHY-B0245
Quantity10 mM * 1 mL
ApplicationsBioactivity, Structure and function analysis, ELISA, SDS-PAGE, Western blotting
Purity99.78%
TypeChemical
Molecular Weight246.30
Molecule NameBusulfan
FormulaC6H14O6S2
Research AreaInflammation/Immunology; Cancer

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(1) Ependymal cell inflammatory activation in response to intracerebral hemorrhageJournal of NeuroinflammationApril 14, 2026Jing Liu, Haopu Lin, Xuefeng He, Yonghe Zheng, Jianan Wu, Qizhen He, Cheng Zhang, Huaping Huang, Xian Yu, Yinan Zhou, et al.type (WT) mice were used as recipients. Recipient mice were preconditioned with busulfan (Cat. No. HY-B0245, MedChemExpress, New Jersey, USA) at 20 mg/kg by intraperitoneal injection on days -7, -5, and -3 before

(2) Restoration of Spermatogenesis is Dependent on Activation of a SPRY4-ERK Checkpoint Following Germline Stem Cell DamageBiology of ReproductionMarch 19, 2026Ying Liu, Tansol Choi, Brad Pearson, Ryan Nachman, Whitney Woo, Na Xu, Ryan Schreiner, Romulo Hurtado, Marco Seandel, Shahin Rafii, et al.once every 24 h for 4 consecutive days per week for 2 weeks total. To induce regeneration, busulfan (HY-B0245, MedChemExpress) was administered to mice by IP injection at a single dose of 10 mg/kg of body weight.

(3) CCL5 promotes angiotensin II-induced cardiac remodeling through regulation of platelet-driven M2 macrophage polarizationTheranosticsJanuary 1, 2026Silin Lv, Mingxuan Zhou, Tiegang Li, Zifan Zeng, Zheng Yan, Yufang Hou, Liu Yang, Fang Zhang, Wenyi Zhao, Yixin Zhou, et al.entire period of Ang II challenge. Platelet depletion/reconstitution model Busulfan model: Busulfan (HY-B0245, MedChemExpress), a selective bone marrow toxin, was used to induce platelet depletion 21. On days 0

(4) Restoration of Spermatogenesis is Dependent on Activation of a SPRY4-ERK Checkpoint Following Germline Stem Cell DamagebioRxivOctober 16, 2025Ying Liu, Tansol Choi, Brad Pearson, Ryan Nachman, Whitney Woo, Na Xu, Ryan Schreiner, Romulo Hurtado, Marco Seandel, Shahin Rafii, et al.once every 24 h for 4 consecutive days per week for 2 weeks total. To induce regeneration, busulfan (HY-B0245, MedChemExpress) was administered to mice by IP injection at a single dose of 10 mg/kg of body weight.

(5) Extracellular Vesicles From Bone Marrow-Derived Macrophages Enriched in ARG1 Enhance Microglial Phagocytosis and Haematoma Clearance Following Intracerebral HaemorrhageJournal of extracellular vesiclesJanuary 1, 2025Hu L, Chen Z, Lu J, Jiang S, Lin H, Zhou J, Wang N, Ding C, Ni W, Peng H, et al.with busulfan was previously published (Peake et al. 2015). In brief, busulfan powder (MedChemExpress, HY‐B0245, USA) was dissolved in DMSO (Sigma‐Aldrich, D2650, USA) to prepare a 12 mg/mL stock solution, which

(6) Riluzole Reverses Blood–Testis Barrier Loss to Rescue Chemotherapy–Induced Male Infertility by Binding to TRPCCellsDecember 6, 2024Rufei Huang, Huan Xia, Wanqing Lin, Zhaoyang Wang, Lu Li, Jingxian Deng, Tao Ye, Ziyi Li, Yan Yang, Yadong Huangweek of acclimatization, the mice accepted a single intraperitoneal injection of busulfan (BSF, Cat# HY-B0245, MedChemExpress, Monmouth Junction, NJ, USA) at the dose of 30 mg/kg·bw. After a week, mice were randomly

(7) Ly6C-high monocytes alleviate brain injury in experimental subarachnoid hemorrhage in miceJournal of neuroinflammationNovember 17, 2023Chen H, Xu C, Zeng H, Zhang Z, Wang N, Guo Y, Zheng Y, Xia S, Zhou H, Yu X, et al.Bone marrow transplantation (BMT) Male mice were injected intraperitoneally with 140 μL of 6 mg/mL busulfan (HY-B0245, MedChemExpress, USA) for the ablation of bone marrow cells at days -7, -5, and -3 before BMT. Donor

(8) Inhibiting Necroptosis of Spermatogonial Stem Cell as a Novel Strategy for Male Fertility PreservationStem cells and developmentApril 15, 2020Xie Y, Chen H, Luo D, Yang X, Yao J, Zhang C, Lv L, Guo Z, Deng C, Li Y, et al.of busulfan-induced gonadotoxicity was generated by two intraperitoneal injections of busulfan (No. HY-B0245; MedChemExpress, NJ) at a total dose of 40 mg kg-1 body weight with an interval of 3 h as we previously described

(9) Establishing a nonlethal and efficient mouse model of male gonadotoxicity by intraperitoneal busulfan injectionAsian journal of andrologyMarch 1, 2020Xie Y, Deng CC, Ouyang B, Lv LY, Yao JH, Zhang C, Chen HC, Li XY, Sun XZ, Deng CH, et al.its toxicity.18 Our previous experiment indicated that the maximal solubility of busulfan (Cat. No. HY-B0245/CS-2224, MedChemExpress, Monmouth Junction, NJ, USA) in DMSO (Cat. No. 196055, MP Biomedicals, Santa

(10) Treosulfan induces distinctive gonadal toxicity compared with busulfanOncotargetApril 10, 2018Levi M, Stemmer SM, Stein J, Shalgi R, Ben-Aharon I.

(11) The role of RIP1 and RIP3 in the development of aplastic anemia induced by cyclophosphamide and busulphan in miceInternational journal of clinical and experimental pathologyJanuary 1, 2014Chen YF, Zhao ZQ, Wu ZM, Zou ZY, Luo XJ, Li J, Xie C, Liang Y.

(12) Antineoplastic agent busulfan regulates a network of genes related to coagulation and fibrinolysisEuropean journal of clinical pharmacologyJune 1, 2012Reimer J, Bien S, Ameling S, Hammer E, Völker U, Hempel G, Boos J, Kroemer HK, Ritter CA.

(13) Busulfan-induced senescence is dependent on ROS production upstream of the MAPK pathwayFree radical biology & medicineJune 15, 2007Probin V, Wang Y, Zhou D.

(14) Induction of glutathione synthesis explains pharmacodynamics of high-dose busulfan in mice and highlights putative mechanisms of drug interactionDrug metabolism and disposition: the biological fate of chemicalsFebruary 1, 2007Bouligand J, Deroussent A, Simonnard N, Opolon P, Morizet J, Connault E, Daudigeos E, Re M, Paci A, Vassal G.

(15) Reduction of primordial follicles caused by maternal treatment with busulfan promotes endometrial adenocarcinoma development in donryu ratsThe Journal of reproduction and developmentDecember 1, 2005Yoshida M, Watanabe G, Shirota M, Maekawa A, Taya K.

(16) Murine male germ cell apoptosis induced by busulfan treatment correlates with loss of c-kit-expression in a Fas/FasL- and p53-independent mannerFEBS lettersSeptember 24, 2004Choi YJ, Ok DW, Kwon DN, Chung JI, Kim HC, Yeo SM, Kim T, Seo HG, Kim JH.

(17) Oral antipyretic therapy: evaluation of benorylate, an ester of acetylsalicylic acid and paracetamolEuropean journal of pediatricsDecember 9, 1975Similä S, Keinänen S, Kouvalainen K.

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Busulfan from MedChemExpress

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Busulfan from MedChemExpress

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