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Neflamapimod
Neflamapimod from MedChemExpress
Be the first to write a review!
Citations:
(9)
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Neflamapimod
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Description
Neflamapimod (VX-745) is a potent, blood-brain barrier penetrant, highly selective inhibitor of
p38α
inhibitor with an
IC
50
for p38α of 10 nM and for p38β of 220 nM. Neflamapimod (VX-745) possesses anti-inflammatory activity
Product Specs
Company Info
Citations
Reviews
Product Specs
Item
Neflamapimod
Company
MedChemExpress
Price
$60.00
Supplier Page
View Company Product Page
Catalog Number
HY-10328
Quantity
10 mM * 1 mL
Applications
Bioactivity, Structure and function analysis, ELISA, SDS-PAGE, Western blotting
Purity
99.32%
Type
Chemical
Molecular Weight
436.26
Molecule Name
Neflamapimod
Formula
C19H9Cl2F2N3OS
Research Area
Inflammation/Immunology
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MedChemExpress
1 Deer Park Drive, Suite F
MONMOUTH JUNCTION
,
NJ
08852
United States
Phone
: US Tel: 609-228-6898
US Fax: 609-228-5909
EU Tel: +4686500910
Email: sales@medchemexpress.com
eu.sales@MedChemExpress.com
Company Profile
Website:
medchemexpress.com
Citations (9)
(1)
Diphtheria toxin activates ribotoxic stress and NLRP1 inflammasome-driven pyroptosis
Journal of Experimental Medicine
October 2, 2023
Kim Samirah Robinson, Gee Ann Toh, Muhammad Jasrie Firdaus, Khek Chian Tham, Pritisha Rozario, Chrissie K. Lim, Ying Xiu Toh, Zhi Heng Lau, Sophie Charlotte Binder, Jacob Mayer,
et al.
used as part of this study: talabostat (
HY-13233
; VbP,
MCE
),
ANS
(
HY-18982
;
ANS
,
MCE
), neflamapimod (
HY-10328
;
MCE
),
M443
(
HY-112274
;
MCE
), harringtonine (
HYN0862
; HTN,
MCE
), puromycin (P9620; Sigma-Aldrich), emricasan
(2)
Cdk5 and GSK3β inhibit fast endophilin-mediated endocytosis
Nature communications
April 23, 2021
Ferreira APA, Casamento A, Carrillo Roas S, Halff EF, Panambalana J, Subramaniam S, Schützenhofer K, Chan Wah Hak L, McGourty K, Thalassinos K,
et al
.
Y-kinases in this study, Calbiochem 245834),
GNE-7915
(called LRRK2i in this study,
MedChemExpress
Hy-10328
),
GSK2334470
(called PDKi in this study,
Cayman
18095
),
GW 5074
(called CRAFi in this study, Santa Crux
(3)
JNK, p38, ERK, and SGK1 Inhibitors in Cancer
Cancers
December 21, 2017
Cicenas J, Zalyte E, Rimkus A, Dapkus D, Noreika R, Urbonavicius S.
(4)
Intra-articular bioactivity of a p38 MAPK inhibitor and development of an extended-release system
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V
June 1, 2015
Pradal J, Zuluaga MF, Maudens P, Waldburger JM, Seemayer CA, Doelker E, Gabay C, Jordan O, Allémann E.
(5)
Selective Brain-Targeted Antagonism of p38 MAPKα Reduces Hippocampal IL-1β Levels and Improves Morris Water Maze Performance in Aged Rats
Journal of Alzheimer's disease : JAD
January 1, 2015
Alam JJ.
(6)
The Discovery of VX-745: A Novel and Selective p38α Kinase Inhibitor
ACS medicinal chemistry letters
October 13, 2011
Duffy JP, Harrington EM, Salituro FG, Cochran JE, Green J, Gao H, Bemis GW, Evindar G, Galullo VP, Ford PJ,
et al
.
(7)
Rapid synthesis of VX-745: p38 MAP kinase inhibition in Werner syndrome cells
Bioorganic & medicinal chemistry letters
September 15, 2007
Bagley MC, Davis T, Dix MC, Rokicki MJ, Kipling D.
(8)
Targeting p38 MAPK inhibits multiple myeloma cell growth in the bone marrow milieu
Blood
January 15, 2003
Hideshima T, Akiyama M, Hayashi T, Richardson P, Schlossman R, Chauhan D, Anderson KC.
(9)
DNA recognition by a new family of type I restriction enzymes: a unique relationship between two different DNA specificities
The EMBO journal
May 1, 1987
Price C, Shepherd JC, Bickle TA.
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Neflamapimod from MedChemExpress
Supplier Page
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$60.00
Product Specs
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