GS967 from MedChemExpress | Biocompare.com

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GS967

Description

GS967 (GS-458967) is a potent, and selective inhibitor of cardiac late sodium current (late I_Na ) with IC₅₀ values of 0.13 and 0.21 µM for ventricular myocytes and isolated hearts, respectively

Product Specs
ItemGS967
CompanyMedChemExpress
Price $67.00Supplier Page View Company Product Page
Catalog NumberHY-12593
Quantity10 mM * 1 mL
ApplicationsBioactivity, Structure and function analysis, ELISA, SDS-PAGE, Western blotting
Purity99.55%
TypeChemical
Molecular Weight347.22
FormulaC₁₄H₇F₆N₃O
Research AreaCardiovascular Disease

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(1) Pre- and Delayed Treatments With Ranolazine Ameliorate Ventricular Arrhythmias and Nav1.5 Downregulation in Ischemic/Reperfused Rat HeartsJournal of cardiovascular pharmacologyOctober 1, 2016Wei X, Zhu A, Zhang Y, Yao S, Mao W.

(2) Use-Dependent Block of Human Cardiac Sodium Channels by GS967Molecular pharmacologyJuly 1, 2016Potet F, Vanoye CG, George AL Jr.

(3) Selective late sodium current blockade with GS-458967 markedly reduces ischemia-induced atrial and ventricular repolarization alternans and ECG heterogeneityHeart rhythmOctober 1, 2014Bonatti R, Silva AF, Batatinha JA, Sobrado LF, Machado AD, Varone BB, Nearing BD, Belardinelli L, Verrier RL.

(4) A novel, potent, and selective inhibitor of cardiac late sodium current suppresses experimental arrhythmiasThe Journal of pharmacology and experimental therapeuticsJanuary 1, 2013Belardinelli L, Liu G, Smith-Maxwell C, Wang WQ, El-Bizri N, Hirakawa R, Karpinski S, Li CH, Hu L, Li XJ, et al.

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