Description
A nucleoside analog with diverse biological activities; active against S. faecalis (IC50 = 0.02 µM); cytotoxic to P388 and A549 cells (IC50s = 0.008 and 0.019 µg/ml, respectively); reduces infection of Calu-3 cells by SARS-CoV-2 (EC50 = 0.05 µM) but is toxic to A549-ACE2 and Vero cells; increases survival in a mouse model of schistosomiasis when used at 5 mg/kg in combination with NBMPR-P but is toxic and induces mortality when administered alone at the same dose for four days