Description
An antiviral agent; inhibits replication of wild-type HBV and drug-resistant HBV strains rtA181T, rtA181V, and rtN236T (IC50s = 146, 145, 161, and 131 nM, respectively); inhibits the formation of viral capsids and decreases viral core protein levels in HBV-infected HepG2 and HepG2.2.15 cells at 1 and 10 µM; inhibits HBV replication and reduces the levels of viral intracellular core antigens in mice inoculated with HepAD38 cells at 7.5-60 mg/kg