Description
A PARP14 inhibitor (IC50 = 0.003 µM); selective for PARP14 over PARP1-4, -5a, -5b, -6-12, -15, and -16 (IC50s = 1->100 µM); inhibits IFN-γ-induced PARP14 auto-MARylation in CFPAC-1 cells at 10 µM; induces expression of the genes encoding CCL13, CCL19, and CXCL11 in human kidney cancer tumor explants