Description
A pleuromutilin antibiotic, active against various bacteria, including MRSA (MIC50s = 0.006-1 µg/ml); active against fluoroquinolone- and macrolide-resistant strains of N. gonorrhoeae (MIC90s = 1 mg/L for all); reduces the number of CFUs in a mouse model of S. pneumoniae thigh infection from 10-40 mg/kg; reduces LPS-induced production of TNF-α, IL-6, IL-1β, and GM-CSF, BALF neutrophil infiltration, and lung MMP-9 levels in a mouse model of LPS-induced neutrophilia