Description
An activator of IRE1; induces the expression of the Ire1 target Xpb1s in primary mouse hepatocytes; decreases hepatic expression of the Xbp1 target gene Dnajb9 in wild-type mice and a mouse model of high-fat diet-induced obesity at 50 mg/kg; increases glucose tolerance and suppresses hepatic gluconeogenesis and steatosis in a mouse model of high-fat diet-induced obesity