Description
A cytokine synthesis inhibitor; inhibits the production of TNF-α, IL-1β, IL-6, IL-8, and IL-10 in LPS-stimulated isolated human PBMCs (IC50s = 11, 5.9, 8.8, 7.3m and 9.1 nM, respectively); binds to CPSF3 in cell-free assays; induces accumulation of CXCL8 pre-mRNA in LPS-stimulated SC cells; reduces LPS-induced mortality in a C. parvum-sensitized mouse model of endotoxic shock from 0.3-10 mg/kg, i.v