PD98059 from Cell Signaling Technology

Product Specs
ItemPD98059
CompanyCell Signaling Technology
Price $157.00 Inquire
Catalog Number9900L
Quantity5 mg

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Cell Signaling Technology

3 Trask Lane

Danvers, Massachusetts 01923

United States

Phone: 877-616-CELL
Phone: 978-867-2388
Fax: 866-432-6112
Fax: 978-867-2488

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Website: http://www.cellsignal.com/

Website: Technical Support

(1) Integrative genomic and functional characterization of ADAMTS3 reveals its inflammatory regulation via NF-κB and STAT3 pathways in osteosarcomaJ Cell Commun SignalMay 3, 2026Ehed Muhammed Aymaz, Meltem Alper, Feyza Nur Sav, Tuğşen Aydemir, Feray Köçkarinhibitors for 30 min and then treated with TNF‐α (10 ng/mL) for 6 h. PD98059 (10 μM, Cell Signaling, 9900S) was used for MEK inhibition, Wortmannin (1 μM, Cell Signaling, 99515) was used for PI3K inhibition,

(2) The Calcimimetic R568 Reduces Vascular Smooth Muscle Cell Calcification in Vitro Via ERK 1/2 PhosphorylationInt J NephrolMarch 18, 2025Jonas Engeßer, Philipp Gregor Albert, Matthias Scheuch, Norina Loth, Sylvia Strackechanged every other day. For blocking ERK signaling, PD98059 (Cell Signaling Technology Europe, Cat. no. 9900S) in a final concentration of 10 μM was used. 2.3. Quantitative and Qualitative Analysis of Calcification Quantification

(3) Derivation of transplantable human thyroid follicular epithelial cells from induced pluripotent stem cellsStem Cell ReportsDecember 10, 2024Hendrik J. Undeutsch, Alberto Posabella, Andrea B. Alber, Pushpinder S. Bawa, Carlos Villacorta-Martin, Feiya Wang, Laertis Ikonomou, Darrell N. Kotton, Anthony N. HollenbergIMDM (12440, Gibco) medium for 30–40 min at 37°C. A subset of cells was treated with 20 μM PD98059 (9900L, Cell Signaling Technology), 0.1 mM Dibutyril-cAMP sodium salt (114110, Fisher Scientific), and 0.1

(4) NADPH Oxidase 5 (NOX5) Upregulates MMP-10 Production and Cell Migration in Human Endothelial CellsAntioxidants (Basel)October 3, 2024Javier Marqués, Elena Ainzúa, Josune Orbe, María Martínez-Azcona, José Martínez-González, Guillermo ZalbaWaltham, MA, USA), JNK MAPK inhibitor (JNK-IN-8, SML1246, Sigma Aldrich), and ERK MAPK inhibitor (PD98059, 9900S, Cell Signaling Technology, Danvers, MA, USA) were used at final concentrations of 5 μM in the cell

(5) ALOX15B controls macrophage cholesterol homeostasis via lipid peroxidation, ERK1/2 and SREBP2Redox BiologyJune 1, 2024Yvonne Benatzy, Megan A. Palmer, Dieter Lütjohann, Rei-Ichi Ohno, Nadja Kampschulte, Nils Helge Schebb, Dominik C. Fuhrmann, Ryan G. Snodgrass, Bernhard Brüneand DMNQ (cat. no. ALX-420-027-M005) from Enzo Life Sciences (Lausen, Switzerland), PD98059 (cat. no. 9900L) and SP600125 (cat. no. 8177S) from Cell Signaling Technology (Danvers, MA, USA), liproxstatin-1 (cat.

(6) Chemerin promotes MAPK/ERK activation to induce inflammatory factor production in rat synoviocytesExperimental and therapeutic medicineNovember 1, 2022Wang C, Zhang S, Huang L, Liu J, Zhou Q, Du G, Lao S.divided in half, and half of each plate was treated with a MEK inhibitor (PD98059; 10 µM; cat. no. 9900S; Cell Signaling Technology, Inc.) at 37˚C for 30 min. Then, 100 µl of 0, 0.25, 0.5 or 1.0 µg/ml Reconstituted

(7) UVB-mediated DNA damage induces matrix metalloproteinases to promote photoaging in an AhR- and SP1-dependent mannerJCI insightMay 9, 2022Kim DJ, Iwasaki A, Chien AL, Kang S.Cell Signaling Technologies. CH223191 (C8124), vitamin B12 (V2876), and FA (F7876) were purchased from Sigma-Aldrich. PD98059 (9900S), SB203580 (5633S), and SP600125 (8177S) were purchased from Cell Signaling Technologies. The following

(8) Insulin-binding protein-5 down-regulates the balance of Th17/TregFrontiers in immunologyJanuary 1, 2022Zhu M, Han H, Hu L, Cao Y, Fan Z.anti-CD28 (102102, Biolegend, USA) with a final concentration of 2μg/mL into the medium. PD98059 (20μM, #9900S, Cell Signaling Technology, USA) and SP600125 (20μM, HY-12041, MCE, USA) were added 1h before the treatment

(9) The PI3K/mTOR inhibitor Gedatolisib eliminates dormant breast cancer cells in organotypic culture, but fails to prevent metastasis in preclinical settingsMolecular oncologyJanuary 1, 2022Shor RE, Dai J, Lee SY, Pisarsky L, Matei I, Lucotti S, Lyden D, Bissell MJ, Ghajar CM.name,Manufacturer,Catalogue number MAPKi,PD98059,"Cell Signaling Technologies (Danvers, MA, USA)",9900s Pi3Ki,LY294002,Stem Cell Technologies,72 152 SRCi,PP2,Calbiochem,529 576 JNKi,SP200125,InvivoGen,tlrl‐sp60 PAKi,IPA‐3,Cayman,14

(10) Visfatin promotes intervertebral disc degeneration by inducing IL-6 expression through the ERK/JNK/p38 signalling pathwaysAdipocyteDecember 1, 2021Cui H, Du X, Liu C, Chen S, Cui H, Liu H, Wang J, Zheng Z.(5 × 106 cells per well). Dimethyl Sulphoxide was used to dissolve ERK1/2 inhibitor (PD98059, CST, 9900S, 20 mM), JNK inhibitor (SP600125, CST, 8177S, 25 mM), or p38 inhibitor (SB203580, CST, 5633S, 20 mM).

(11) Microglia induce neurogenic protein expression in primary cortical cells by stimulating PI3K/AKT intracellular signaling in vitroMolecular biology reportsJanuary 1, 2021Lorenzen K, Mathy NW, Whiteford ER, Eischeid A, Chen J, Behrens M, Chen XM, Shibata A.or 40 µM to the cortical cultures. The following inhibitors were tested: MAPK inhibitor PD98059 (Cat#9900S), PI3K/AKT inhibitor LY294002 (Cat#9901S), PKC and Glycogen synthase kinase-3 inhibitor GF109203X (Cat#984,150),

(12) Sulforaphane-cysteine inhibited migration and invasion via enhancing mitophagosome fusion to lysosome in human glioblastoma cellsCell death & diseaseOctober 1, 2020Zhou Y, Wang Y, Wu S, Yan Y, Hu Y, Zheng Z, Li J, Wu W.(Dallas, Texas, USA). Anti-p-ERK1/2 (9101S), anti-ERK1/2 (9102S), anti-LAMP1 (15665), and PD98059 (9900S) were obtained from Cell Signaling Technology (Danvers, MA, USA). Anti-Stathmin-1 (D260545) and anti-pStathmin-1

(13) Head and Neck Cancer Metastasis and the Effect of the Local Soluble Factors, from the Microenvironment, on Signalling Pathways: Is It All about the Akt?CancersJuly 28, 2020Ahmed H, Ghoshal A, Jones S, Ellis I, Islam M.µM Gefitinib (EGFR inhibitor) 4765S Cell Signaling Tech., Denver, MI, USA 10 µM PD98059 (MAPK inhibitor) 9900L Cell Signaling Tech., Denver, MI, USA 50 µM TGFβRI kinase inhibitor VII 616458 Calbiochem, San

(14) Cell proliferation and anti-oxidant effects of oxytocin and oxytocin receptors: role of extracellular signal-regulating kinase in astrocyte-like cellsEndocrine RegulationsJuly 1, 2020Mohammed M. Alanazi, Tomas Havranek, Jan Bakos, Luigi X. Cubeddu, Ana M. CastejonL-371, 257 (OXTA, Santa Cruz Biotechnology, CAS 162042-44-6), or the MEK1/2 inhibitor PD98059 (CST 9900S, Cell Signaling Technology, USA) for 24, 48, 72 and 96 h. The culture medium with treatment was changed

(15) Group III metabotropic glutamate receptors gate long-term potentiation and synaptic tagging/capture in rat hippocampal area CA2eLifeApril 20, 2020Dasgupta A, Lim YJ, Kumar K, Baby N, Pang KLK, Benoy A, Behnisch T, Sajikumar S.(#V1121, Promega, Madison, Wisconsin) was stored as 20 mM stock in DMSO. The other MEK inhibitor PD98059 (#9900L, Cell Signaling Technology, Beverly, Massachusetts) was stored as 50 mM stock in DMSO at −20°C. Both

(16) The Vibrio cholerae MARTX toxin silences the inflammatory response to cytoskeletal damage before inducing actin cytoskeleton collapseScience SignalingJanuary 16, 2020Patrick J. Woida, Karla J. F. Satchell#926–68071). Chemical reagents used in this study were ERK MAPK inhibitor PD98059 (Cell Signaling Technology, #9900L), p38 MAPK inhibitor SB202190 (Cell Signaling Technology, #S7067), JNK MAPK inhibitor SP600125 (Abcam,

(17) PGK1 facilities cisplatin chemoresistance by triggering HSP90/ERK pathway mediated DNA repair and methylation in endometrial endometrioid adenocarcinomaMolecular medicine (Cambridge, Mass.)March 29, 2019Zhou JW, Tang JJ, Sun W, Wang H.Cell Signaling Technology (8132S) and used at 1 μM. ERK inhibitor PD98059 was purchased from Cell Signaling Technology (9900S) and used at 20 μM. Cells were cultured in DMEM:F12 medium (Life Technologies, Carlsbad, USA) in a humidified

(18) TGF-β downregulates CAIII expression via MAPK and PI3K signaling pathways in colon carcinoma and osteosarcoma cellsArchives of Biological SciencesJanuary 1, 2019Turkoglu Aydogan, Derya Okuyan, Feray Kockarinhibitors Wortmannin, a PI3K inhibitor (99515), and PD98059, mitogen-activated protein kinase 1 (MEK-1) inhibitor (9900S), were obtained from Cell Signaling, USA and were used for inhibition of different cellular signaling

(19) Modulation of Gut Microbiota Composition by Serotonin Signaling Influences Intestinal Immune Response and Susceptibility to ColitisCellular and molecular gastroenterology and hepatologyJanuary 1, 2019Kwon YH, Wang H, Denou E, Ghia JE, Rossi L, Fontes ME, Bernier SP, Shajib MS, Banskota S, Collins SM, et al.antagonist; Cat. # 22978-25-2; Caymen Chemicals, Ann Arbor, MI), and PD98059 (MEK inhibitor; Cat. # 9900L; Cell Signaling Technology, Danvers, MA) were prepared according to the manufacturer's manual. Cell Culture

(20) EZH2 inhibits autophagic cell death of aortic vascular smooth muscle cells to affect aortic dissectionCell death & diseaseFebruary 7, 2018Li R, Yi X, Wei X, Huo B, Guo X, Cheng C, Fang ZM, Wang J, Feng X, Zheng P, et al.Selleck), Chloroquine (20 μM, C6628; Sigma-Aldrich), UNC1999 (5 μM, S7165; Selleck), or PD98059 (50 μM, #9900L; Cell Signaling Technology), respectively. The LDH release was detected by using a cytotoxicity LDH

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PD98059 from Cell Signaling Technology

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PD98059 from Cell Signaling Technology

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