Description
A CD38 inhibitor (IC50 = 17.7 nM); selective for CD38 over PARP1, SIRT1, and Nampt at 100 nM; increases NAD+ levels in MEFs at 200 nM; decreases glucose and insulin levels in an intraperitoneal glucose tolerance test in 2-year-old, but not 1-year-old or 3-month-old, mice at 10 mg/kg twice per day; prevents age-dependent decreases in exercise capacity and physical activity and increases in DNA damage in liver and skeletal muscle tissues in mice