Description
An agonist of PPARα; activates PPARα in HepG2 cells in a reporter assay at 1 µM but does not activate PPARβ or PPARγ at 10 µM; prevents T0901317-induced triglyceride accumulation in HepG2 cells at 3 µM; scavenges ROS and peroxynitrite in cell-free assays (IC50s = 39.7 and 2.39 µM, respectively); inhibits β-glucuronidase and tyrosinase (IC50s = 8.9 and 0.01 µM for the bovine liver and mushroom enzymes, respectively); reduces age-induced increases in liver weight and triglyceride levels in a rat model of hepatic steatosis at 5 mg/kg