Description
An inhibitor of acid ceramidase (IC50 = 52 nM); selective for acid ceramidase over neutral ceramidase and the cysteine protease papain at 3 µM; inhibits acid ceramidase in PC3 MC cells (IC50 = <1 µM), as well as induces accumulation of ceramides in the same cells; completely inhibits anchorage-independent colony formation by PC3 MC cells at 5 µM