Description
A lignan with diverse biological activities; inhibits the binding of PAF to isolated rabbit platelet plasma membranes (IC50 = 4.5 µM); inhibits RANKL- and M-CSF-induced osteoclast formation in mouse bone marrow-derived macrophages at 3-100 µM; protects against cytotoxicity induced by human Aβ (25-35) in primary rat hippocampal neurons at 10 µM; reduces acetic acid-induced abdominal constrictions in mice and carrageenan-induced paw edema in rats at 20 mg/kg