Description
An inhibitor of acid ceramidase (Ki = 97.1 nM); decreases levels of S1P and increases total ceramide levels in OCI-AML-2 cells at 2.5 µM; induces apoptosis in primary AML cells at 10 and 20 µM; reduces leukemic burden in MV4-11 and U937 AML mouse xenograft models at 5 mg/kg