Description
A κ-opioid receptor antagonist (Ki = 0.807 nM); selective for KOR over the µ- and δ-opioid receptors (Kis = 24 and 155 nM, respectively); reverses U-69593-induced decreases in nocifensive behavior in the formalin test in rats (ED50 = 0.4 mg/kg); reverses U-69593-induced disruptions in prepulse inhibition in rats; reduces immobility time in the forced swim test in mice at 10 mg/kg; reduces alcohol self-administration and the progressive ratio breakpoint in rats at 10 mg/kg