Description
DMOG is known for its ability to inhibit PHD (prolyl hydroxylase domain)-containing proteins, activating HIF1alpha (1,2) and inhibiting JMJD2A (IC50 = 2.5uM) (3). It also has been shown to offer neuroprotective effects and ameliorate neuronal cell death caused by neurotrophin deprivation (4). DMOG also inhibits the ATR/CHK1/p53 pathway and suppresses apoptosis induced by DNA damage (5)