Description
RO-7 is a novel small molecule, broad-spectrum inhibitor of influenza acidic polymerase (PA) protein endonuclease activity with EC50 of 3.2-16nM in MDCK cells; inhibits transcription and genome replication steps in the influenza virus cycle, demonstrates activity against NAI-resistant and -susceptible seasonal influenza A and B viruses; also shows activity against avian-origin A (H5N1), A (H7N9), and A (H9N2) influenza viruses