Description
PIK-93 is a potent, synthetic PI4K inhibitor with IC50 of 19nM (PI4KIIIbeta), also inhibits PI3Kgamma and PI3Kalpha with IC50 of 16nM and 39nM, respectively; also inhibits other PI3Ks, including PI3Kalpha, beta, and delta, with IC50 values of 39nM, 0.59uM, and 0.12uM, shows no inhibitory effect against a panel of other kinases; significantly inhibits the conversion of [3H]serine-labeled endogenous ceramide to sphingomyelin, reduces carbachol-induced translocation of TRPC6 to the plasma membrane and net Ca2+ entry in T6.11 cells at 300nM; also demonstrates anti-enterovirus effects by inhibition of both poliovirus and HCV replication with EC50 of 0.14uM and 1.9uM, respectively