Description
A potent and selective NOD1 inhibitor with IC50 of 0.56uM; no inhibition on NOD1, TNFalpha (IC50>20uM) and dIKKgamma/NEMO, MYD88, FLIP, CARD6, APAF1 or NLRC4; inhibits IL-8 production induced by NOD1 ligand and gamma-tri-DAP-induced expression of the prototypical NF-kappaB target gene IkappaBalpha at the mRNA level