Description
Spleen tyrosine kinase (Syk) is a non-receptor tyrosine kinase that, upon phosphorylation, binds to immunoreceptor tyrosine-based activation motifs of FcRgamma chains and mediates downstream signaling related to platelet function and inflammation. Syk inhibitor II is a cell-permeable, pyrimidine-carboxamide compound that selectively and reversibly blocks Syk (IC50=41nM) in an ATP-competitive manner. It is much less potent against PKCepsilon, PKCbetaII, ZAP-70, Btk, and Itk (IC50s=5.1, 11, 11.2, 15.5, and 22.6uM, respectively)