Description
IIIC3 (Gallocyanine; Dickkopf inhibitor IIIC3) is a small-molecule inhibitor of Wnt antagonist Dickkopf with EC50 of 5uM for reversing DKK1 CM-mediated Wnt inhibition; inhibits the binding of DKK1-alkaline phosphatase (AP) to HEK293 cells expressing the wild-type LRP5 or LRP5 mutant with IC50 of 3uM; reduces basal blood-glucose concentrations and improves glucose tolerance in mice