Description
SW-100 (SW100) is a potent, selective, brain penetrable HDAC6 inhibitor with IC50 of 2.3nM, displays >1,000-fold selectivity over all other class I, II, and IV HDAC isoforms; selectively inhibits HDAC6-CD2 and enhances alpha-tubulin acetylation in cells with no effect on histone acetylation and selectively restores the impaired acetylated alpha-tubulin levels in the hippocampus of Fmr1-/- mice; ameliorates several memory and learning impairments in Fmr1-/- mice, thus modeling the intellectual deficiencies associated with Fragile X syndrome (FXS)