Description
SirReal2 (MZ25) is a novel potent, selective Sirt2 inhibitor with IC50 of 0.435uM; displays >1,000-fold more potently than Sirt1, Sirt3, Sirt4, Sirt5 and Sirt6; increases alpha-tubulin acetylation in HeLa cells, significantly results in a dose-dependent depletion of BubR1