Description
Avanbulin (BAL27862, BAL-27862) is a novel microtubule-destabilizing agent that potently inhibits tubulin assembly at 37 degree C with IC50 of 1.4uM in tubulin-binding assays; potentli bindis to unassembled tubulin with a stoichiometry of 1 mol/mol tubulin and a dissociation constant of 244 +/- 30nM, BAL27862 bound to tubulin independently of vinblastine, without the formation of tubulin oligomers; inhibits tumor cell proliferation through activation of the spindle assembly checkpoint, inhibits EB1-dependent migration and invasion and promotes differentiation of glioblastoma stem-like cells both in vitro and in vivo