Description
A potent and selective BTK inhibitor with IC50 of 4nM in the enzymatic assay; shows high selectivity against a panel of 369 kinases; blocks Fcepsilon receptor cross-linking-induced degranulation in mast cells (IC50=2.9nM) and Fcgamma receptor engagement-mediated TNFalpha production in monocytes (IC50=7.0nM); robust anti-inflammatory and bone-protective effects in mouse CIA and rat adjuvant-induced arthritis (AIA) models. Rheumatoid Arthritis Preclinical