Description
A potent, selective, and cell-active dual inhibitor of PRMT4 and PRMT6 with IC50 of 34 +/- 10nM and 43 +/- 7nM, respectively; displays >30-fold and >300-fold selectivity over PRMT8 and PRMT1/3, does not inhibits PKMTs, DNMTases, RNA methyltransferases; reduces the H3R2me2a mark in HEK293 cells with IC50 of 0.97uM