Description
A highly potent, selective, and orally bioavailable factor Xa (FXa) inhibitor with Ki of o.19nM, >5,000-fold selectivity over a series of related serine proteases; inhibits thrombus formation in a dose-dependent manner with an ID50 of 1.6uMol kg-1 h-1 in rabbit arterio-venous shunt thrombosis model.Thrombosis Phase 2 Discontinued