Description
7-Hydroxymethotrexate is a phase I metabolite of MTX, which is converted by hepatic aldehyde oxidases. 2 Formulations containing methotrexate have been used in the treatment,of cancer, autoimmune diseases, ectopic pregnancy, and for the induction of medical abortions. Elimination of 7-hydroxy MTX is associated with the multi-drug transporters Abcc2, Abcc3, and Abcg2 in transgenic mouse models