Description
GW-766994 (GW766994) is a potent, selective, orally available CCR3 antagonist with pKi of 7.86 for inhibiting eotaxin-induced eosinophil chemotaxis in vitro assays; reverses CCL11-induced activation of CDK5 at 10uM in rat neurons expressed CCR3, blocks CCL11-induced the production of Abeta and dendritic spine loss in the hippocampal neuronal cultures