Description
A potent, highly specific JAK3 inhibitor with IC50 of 4nM; shows only modest inhibition of PKA (6.7uM) and LCK (10.9uM) in vitro; selectively downregulates JAK2 and JAK3 mRNA, corresponding to changes observed at the protein level; shows in vivo activity consistent with in vitro enzyme and whole blood assays (39 ng/ml); dose-dependently inhibits the DTH response in mice with EC50 of 5mg/kg