Description
IC 86621 is a potent DNA-PK inhibitor with IC50 of 135nM, also inhibits p110beta (IC50=135nM), less potent for p110alpha/gamma/delta (IC50=880-1, 400nM); directly inhibits the repair of DNA DSBs and consequently enhances the cytotoxicity of physical and chemical agents that induce DSBs but not other DNA lesions