Description
Netarsudil (AR-13324) is a potent, selective ROCK inhibitor with Ki of 4.2nM for ROCK2; 11 kinases are inhibited >90% in a panel of 422 kinases, only ROCK1 and ROCK2 (each 93% inhibition) and PKC (delta, 91%, and eta, 93% inhibition); exhibts improved bioavailability, demonstrates an effective and sustained IOP reduction for 24h after dosing; a novel ocular hypotensive agent for the treatment of glaucoma. Other Indication Approved