Description
Linarin (acacetin-7-O-beta-d-rutinoside) shows selective dose dependent inhibitory effect on acetylcholinesterase. Linarin alleviates GalN/LPS-induced liver injury by suppressing TNF-alpha-mediated apoptotic pathways. Linarin prevents A beta-induced neurotoxicity through the activation of PI3K/Akt, which subsequently inhibits GSK-3b and up-regulates Bcl-2. The piperine significantly enhanced the oral absorption of Linarin in rats by inhibiting P-glycoprotein mediated cellular efflux during the intestinal absorption and likely simultaneously by inhibiting the metabolism of Linarin