Description
IBR2 is a novel small molecule RAD51 inhibitor that specifically binds to RAD51 and disrupts the BRC repeats of BRCA2/RAD51 interaction with IC50 of 0.11uM; disrupts RAD51 multimerization and inhibits RAD51-mediated HR repair, reduces RAD51 protein levels via proteasome-mediated degradation; inhibits cell growth and induces apoptosis in imatinib-resistant T315I-Ba/F3 cells; significantly prolongs animal survival in a murine imatinib-resistant CML model bearing the T315I Bcr-abl mutation