Description
A highly potent, selective G9a inhibitor with Ki of 63 pM; inhibits G9a and GLP with IC50 of 6nM and 23nM in CLOT biochemical assays; dispalys >1000-fold selectivity for G9a over SET7/9, SET8, PRMT3 and JMJD2E (IC50>4uM); but lacks sufficient cellular potency