Description
Celastrol (Tripterin) is an active compound extracted from Chinese medicine Thunder of God Vine, is a potent proteasome inhibitor, preferentially inhibits the chymotrypsin-like activity of 20S proteasome with IC50 of 2.5uM; also inhibits 26S proteasome in intact androgen-independent PC-3 and androgen-dependent LNCaP prostate cancer cells at 1-5uM, induces apoptotic cell death, and accumulates ubiquitinated proteins and natural proteasome substrates, IkappaB-alpha, Bax, and p27, and/or suppression of AR protein expression; promotes significant tumor growth inhibition and massive apoptosis induction in vivo