Description
(R)-DRF053 dihydrochloride (DRF053) is a potent, cell-permeable, dual CK1/CDK inhibitor with IC50 of 14nM, 220nM and 80nM for CK1, CDK5/p25 and CDK1/cyclin B, respectively; exhibits antiproliferative activity against human neuroblastoma SH-SY5Y cells with EC50 of 17.2uM, prevents the CK1-dependent production of amyloid-beta in a cell model; specifically increases the number of duct-derived beta-cells without affecting their proliferation