Description
CHMFL-ABL-053 is a potent, selective and orally available Bcr-Abl/Src/p38 kinase inhibitor with IC50 of 70/62/90nM; no inhibitory activity against c-Kit (>10uM); inhibits the proliferation of CML cell lines K562 (GI50=14nM), KU812 (GI50=25nM), and MEG-01 (GI50=16nM); completely suppresses tumor progression in the K562 cells inoculated xenograft mouse model with 50mg/kg/day dosage treatment