Description
AS2541019 is a novel potent, selective, orally active PI3Kdelta inhibitor with IC50 of 20.1nM, >100-fold selectivity over other PI3K isoforms; inhibits Akt phosphorylation in human Ramos B cell line with IC50 of 14.3nM, effectively inhibits anti-IgM stimulated B cell proliferation and human B cell proliferation with IC50 of 4.3 and 3.6nM, respectively; significantly inhibits both T-dependent and T-independent de novo antibody production in peripheral blood in vivo; significantly prolongs graft survival time by inhibiting xenoreactive antibody production in rat concordant xenotransplant model