Description
LP99 is the first potent and selective BRD7/9 bromodomain inhibitor with Kd of 99nM for BRD9; inhibits IL" 6 secretion from THP" 1 cells in a dose" dependent manner; decreases BRET for both BRD7 and BRD9 in both the H3.3 and H4 systems in a dose" dependent manner, with cellular IC50 values in the low micromolar range for both histones