Description
INF39 (NLRP3 inhibitor INF39) is a nontoxic, irreversible, orally available NLRP3 inhibitor that inhibits NLRP3 ATPase and decreases interleukin-1beta release from macrophages; significantly inhibit ATP- and nigericin-induced IL-1beta release in mouse bone marrow derived macrophages (BMDM) at 10uM, reduces colonic myeloperoxidase, IL-1beta, and TNF Levels in DNBS-treated rats