Description
AMG 511 is a potent and orally available pan inhibitor of class I PI3Ks(Kis of 4,6,2 and 1 for PI3Kalpha, beta, delta and gamma, respectively). It exhibits anti-tumor activity in mouse glioblastoma xenograft model[1]. AMG 511 significantly suppresses PI3K signaling that is indicated by p-Akt (Ser473) decrease