Description
A potent, dual class I PI3K/mTOR inhibitor with IC50 of 2/3/3/15/ for p110alpha/beta/delta/gamma, respectively; also inhibits TORC1 (>80% inhibition at 0.5uM) and DNA-PK (IC50=14nM), 15- to 20-fold less activity against class II PI3K C2beta (IC50=43nM), >1, 300-fold selectivity over the class III PI3K Vsp34; potently inhibits proliferation and invasion of a wide variety of human cancer cells in vitro; shows activity in cancer xenograft models