Description
A non-selective agonist of the dopamine D3 receptor (Ki=0.71nM); has 10-fold selectivity for the D3 receptor over the D2, D4, and D5 receptors and 100-fold selectivity for the D3 receptor over the D1 receptor; behaves as a full agonist of D1, D2, and D3 with similar potencies (EC50) in functional assay; also demonstrates significant affinity at alpha-adrenergic (alpha2B, Ki=27nM) and serotonin receptors (5-HT1A Ki=30nM); significantly attenuates MPTP-induced acute cell degeneration in mouse model. Parkinson's Disease Approved