Description
A potent and selective Raf inhibitor with biochemical IC50 of 3.8/14/23nM for BRaf V600E/BRAF/CRAF, respectively; shows pERK inhibition in A375 and COLO829 cells with IC50 of 3.5nM and 2.1nM, respectively; and do not elicit paradoxical ERK1/2 activation in mutant RAS expressing cells; exhibits effectivity in both BRAFV600E and certain non-V600 LA models, in vitro and in vivo. Skin Cancer Phase 2 Clinical